Winks goes off for Wanyama at the base of midfield with just a minute or so to play.
90' +1
Southampton have everyone forward and Bertrand dinks the ball into the box. Obafemi wins the first ball but it bounces straight to Lloris.
89'
Long's first contribution is to intercept a pass meant for Armstrong and then proceed to pass the ball straight out of play when trying to find him.
88'
S. Long enters the game and replaces S. Boufal.
Boufal goes off for an extra striker in Long as Hasenhuttl rolls the dice for the last time.
87'
SHOT! Armstrong goes alone as he cuts in from the left and strikes low at the near post, but Lloris can gather comfortably.
83'
M. Obafemi enters the game and replaces D. Ings.
Ings, who has worked hard up front, is replaced by Obafemi for the remainder of the game as Hasenhuttl searches for a late equaliser.
82'
J. Bednarek gets yellow.
Bednarek now picks up a yellow card of his own for a challenge on Kane.
81'
The game is getting stretched now, despite Pochettino's best efforts to prevent that from happening, but neither side has been able to find a killer pass in the final third.
79'
S. Armstrong enters the game and replaces J. Vestergaard.
Meanwhile, Vestergaard is off for Armstrong as Hasenhuttl sacrifices a defender for an attacking midfielder.
Minute
Description
78'
E. Dier enters the game and replaces T. Ndombélé.
Dier replaces Ndombele as Pochettino introduces a more combative presence into the game in an attempt to see the win out.
76'
Both sides are hitting the wide areas and trying to work the ball into the box when they get forward, but neither is finding that route to goal particularly successful so far.
74'
Spurs have just started to creep out of their half in the last few minutes. Yoshida is furious as he wants a free-kick for a foul by Kane on him, but a corner is awarded instead.
72'
Southampton are piling the pressure on and look to be on the verge of unpicking the hosts. They're getting closer.
68'
M. Yoshida gets yellow.
Yoshida is forced to commit a foul and earns his side's first yellow card of the day.
66'
Lloris makes a meal of a simple catch from Boufal's curled pass towards the back post, but he keeps it the right side of the line.
64'
É. Lamela enters the game and replaces Son Heung-Min.
Son, who was bright in the first half but has been playing almost as a full-back since the break, is now replaced by Lamela.
62'
OVER! Yoshida meets a corner but it deflects off a Spurs defender and drops onto the roof of the net and behind for another corner.
60'
Southampton are penning Spurs in and piling on the pressure. They're working the ball around patiently, probing for an opening and not letting the hosts break.
58'
OVER! From the resulting corner, Hojbjerg tries a volley and sticks the ball straight into the stands. That was both very high and very wide of the goal.
55'
Son catches the legs of Boufal and concedes a free-kick in a very promising position. Ward-Prowse is eyeing this one up.
53'
No clear-cut opportunities for either side since the restart so far. Pochettino's side are doing their jobs efficiently at the moment, closing off spaces and making it difficult for Southampton.
51'
Southampton have to be careful as they are once again caught out on the break. Vestergaard just about deals with Kane and the chance is snuffed out, but a third Spurs goal could be a killer blow.
49'
Bertrand and Redmond link up well down the left as the former breaks into the box. He fizzes it across the box but nobody has made a run to take advantage.
48'
Spurs are only pressing as far as the halfway line since the restart. Pochettino is clearly keen to avoid his 10 men being stretched and they are in an organised shape as they look to preserve their lead.
46'
Southampton get us back underway!
45' +4
HALF-TIME: TOTTENHAM 2-1 SOUTHAMPTON
45' +2
Southampton are running hard as they try to haul themselves level again. They threw away the lifeline that was handed to them and they now need to work to get back on terms.
43'
H. Kane has scored a goal for Tottenham Hotspur! Assist by C. Eriksen.
GOAL!! SPURS ARE BACK IN FRONT! Southampton over-commit men forward and suddenly Spurs can break! It's worked around quickly and Kane slots the ball clinically into the bottom corner to make it 2-1. Southampton were ahead for less than five minutes.
The passage of play in the final third was fluid and Eriksen fed Kane in the box as the move swept from right to left, and the striker had plenty of time to take a touch and fire home.
39'
D. Ings has scored a goal for Southampton!
GOAL!! WHAT A HOWLER FROM LLORIS! Alderweireld passes the ball back to Lloris on his line and the goalkeeper's first touch is a little heavy, but he still has plenty of time to play it. However, he instead attempts a Cruyff turn as Ings closes him down, but misses the ball entirely, allowing Ings to poke the ball in! It's 1-1!
35'
Sissoko has gone to fill in at right-back until half-time, leaving Spurs in a 4-3-2 formation.
31'
S. Aurier gets a second yellow card and is sent off.
RED CARD! Aurier pulls Bertrand back as he's released in behind and picks up a second yellow card! He's off and Spurs are down to 10 men!
29'
Son is proving Spurs' main creative outlet down the left, regularly getting the better of makeshift wing-back Ward-Prowse. This time, he fizzes a low cross into the six-yard box as Kane makes a run, but it's hacked clear.
27'
S. Aurier gets yellow.
Aurier's challenge on Boufal is poor and he earns himself the first yellow card of the day.
26'
SHOT! Southampton try to equalise immediately as they break into the final third, but Redmond's shot is blocked as Spurs scramble men back to defend.
24'
T. Ndombélé has scored a goal for Tottenham Hotspur! Assist by Son Heung-Min.
GOAL!! Tottenham take the lead! Son pokes the ball across to Ndombele from the left again and this time the midfielder can take a touch before shooting. It's straight at Gunn, who should really do a lot better despite the slight deflection. It's 1-0 to the hosts!
Son collected on the left side of the box following Eriksen's cross and just managed to get it to Ndombele in space.
20'
SHOT! Spurs try a short-corner routine in which Son is found on the byline. He tries to jink his way past a crowd of defenders but is eased off it and Southampton break, but Redmond's shot is blocked away.
18'
CHANCE! The ball sits up nicely for Kane to volley at the back post, but he misses the ball entirely and Southampton gratefully get the ball away.
16'
SHOT! Boufal drives through the middle but runs into traffic on the edge of the box. He cuts wide onto his right foot and curls an effort at goal, but he doesn't get enough power behind it and Lloris holds on comfortably.
14'
Southampton are pressing well off the ball, making it difficult for Spurs to have the time and space to fashion clear-cut chances.
12'
CHANCE! Ndombele pings a lovely ball over the top to Son on the left side of the box. He tries to cushion it into the path of Kane, but doesn't get enough on it and Gunn is out to gather.
8'
A fantastic, raking ball over the top finds Son in behind as he charges into the box, but Bednarek makes an excellent challenge to deny the forward, who was clean through on goal!
6'
OVER! Ings then repeats the trick, putting the ball over the bar from inside the box.
5'
OVER! Yoshida manages to get his head to a corner but can't really threaten with it and it loops harmlessly over the bar.
3'
Saints right-back Cedric Soares picked up an injury in the warm-up and was replaced in the starting XI by Vestergaard - a fourth change from their midweek derby win - and now Ndombele is on the turf and requires brief treatment before getting back to his feet.
1'
We're off at the Tottenham Hotspur Stadium!
Hello and welcome to our LIVE coverage of the Premier League fixture between Tottenham and Southampton.
Spurs will be hoping to bounce back from their shock EFL Cup exit on penalties at the hands of League Two outfit Colchester United, while Southampton fared rather better in midweek, beating rivals Portsmouth 4-0 on their own patch.
Tottenham XI (4-3-1-2): Hugo Lloris; Serge Aurier, Toby Alderweireld, Jan Vertonghen, Danny Rose; Moussa Sissoko, Harry Winks, Tanguy Ndombele; Christian Eriksen; Harry Kane, Son Heung-min
Tottenham substitutes: Lucas Moura, Paulo Gazzaniga, Eric Dier, Erik Lamela, Dele Alli, Victor Wanyama, Ben Davies
Southampton XI (3-4-2-1): Angus Gunn; Jan Bednarek, Maya Yoshida, Jannik Vestergaard; James Ward-Prowse, Oriol Romeu, Pierre-Emile Hojbjerg, Ryan Bertrand; Sofiane Boufal, Nathan Redmond; Danny Ings
Southampton substitutes: Shane Long, Yan Valery, Harry Lewis, Kevin Danso, Michael Obafemi, Stuart Armstrong
Both managers may have had to change their half time team talk more than once as the break approached. Neither will be pleased with the opening 45 minutes, but both will feel that the game is still there to be won.
Spurs face Bayern Munich next in the Champions League, while Southampton face Chelsea at home in the Premier League.
Thank you for joining our coverage, we hope you enjoyed the game. Until next time, goodbye!
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